Claudin18.2/ KATOIII
CBP74132
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| I. Background | |
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Claudin18是位于细胞膜表面紧密连接的主要成分，它在维持细胞极性和屏障功能以及促进耐酸能力方面起着重要作用。CLDN18的第一个外显子可以选择性剪接，形成两个具有高度同源氨基酸序列的不同剪接突变体(CLDN18.1和CLDN18.2)。跨膜蛋白CLDN18由两个细胞外环、四个跨膜结构域和一个细胞质结构域组成。 |
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| II. Introduction | |
| Host Cell: |
KATOIII |
| Expressed gene: |
Claudin18.2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Species: | Homo sapiens, human |
| Tissue: | Stomach; derived from metastatic site: pleural effusion and supraclavicular and axillary lymph nodes and Douglas cul-de-sac |
| Disease: | Gastric carcinoma |
| Morphology: | Spherical |
| Growth Properties: | mixed, adherent and suspension |
| IV. Representative Data | |
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1. Claudin18.2/ KATOIII |
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