NOMO-1（人白血病细胞）
CBP60515
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| I. General information | |
| Synonyms: | NOMO-1 |
| Background: | established from the bone marrow of a 31-year-old woman with acute myeloid leukemia (AML FAB M5a) at 2nd relapse; described in the literature to show strong lysozyme activity in the cytoplasm, phagocytic activities, and cells are responsive to induction of differentiation with TPA; cells carry the t(9;11)(q23;p22) KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) alteration |
| Species: | human (Homo sapiens) |
| Tissue: | N/A |
| Disease: | acute myeloid leukemia |
| Gender: | N/A |
| Morphology: | single round cells growing in suspension; |
| Growth Mode: | N/A |
| Doubling Time: | ca. 35 hours |
| DNA Profile: | N/A Our Cell Line Authentication Service |
| Culture Medium: |
RPMI1640+10%FBS NOMO-1完全培养基，# CBP60515M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Mycoplasma: | negative in microbiological culture, PCR assays |
| Immunology: | CD3 -, CD4 +, CD13 +, CD14 -, CD15 +, CD19 -, CD33 +, CD34 -, HLA-DR +; image |
| Fingerprint: | multiplex PCR of minisatellite markers revealed a unique DNA profile |
| Species: | confirmed as human by cytogenetics |
| Cytogenetics: | human hyperdiploid karyotype with 8% polyploidy - 46-47<2n>XX, +8, -13, +mar, add(7)(q32), der(9)del(9)(p11p13-21)t(9;11)(p22;q23), t(9;13)(q13;q11), der(11)t(9;11)(p22;q23) - carries reciprocal t(9;11) with rearrangement of KMT2A (MLL) - matches published karyotype |
| Molec. Genetics: | expression of fusion gene KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) confirmed by RT-PCR |
| Virus | PCR: EBV -, HBV -, HCV -, HIV-1 -, HIV-2 -, HTLV-I/II -, MLV -, SMRV - |
| Comments: | For more information, please contact us (4008-750-250). |
